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KMID : 0377619670120010089
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Korean Jungang Medical Journal
1967 Volume.12 No. 1 p.89 ~ p.96
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Influence on Rabbit Erythrocyte and Plasma Cholinesterase of a Single Dose of a Few Organophosphate and Carbamate Pesticides Sold and Used in Korea.
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金漢燮/Kim, Han-Seob
金相仁/Kim, Sang In
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Abstract
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The in vivo effects of anticholinesterases in general vary not only on species, sex, means of administration, vehicle with which an anticholinesterase is administered, etc., but among others on the quality e. g. stability and purity of the preparations. There has been no report, experimental or clinical, concerning the influence of those anticholinesterase pesticides, sold and used in Korea, on the blood cholinesterase in mammals. The erythrocyte and plasma cholinesterase activities were traced in 20 grouped rabbits 6,24 and 72 hours after a single oral administration of 3 organophosphate anticholinesterases-Parathion, EPN and Malathion, and one carbamate anticholinesteraseDithane, -all korean products-in doses of one-third of estimated LD50´s for rabbits.
1) Following doses of these compounds an inhibition of cholinesterase was noted in both erythrocyte and plasma, especially at 6 hours.
2) Plasma cholinesterase could be more depressed than erythrocyte enzyme (in cases of Parathion and Dithane groups) when the enzyme depression was marked, i.e. at 6 hours post-administration.
3) At 24 hours there was a tendency that the cholinesterase activities in erythrocyte and plasma dissociate from each other with the plasma enzyme mostly recovered, which the erythrocyte enzyme did not.
4) By 72 hours the erythrocyte cholinesterase was belatedly but mostly recovered.
5) Marked individual variation in cholinesterase activity was noted in each expert mental group.
6) Measurements of cholinesterase activities in 12 normal adult Korean males and 12 females were tried using Michel’s method, with the results (expressed as ?pH/hr): males: erythrocyte, 0.765± 0.121 (S. D. =Standard Deviation), plasma, 0.685 ±0.142 (S.D.); females: erythrocyte, 0.732 ±0.059 (S.D.), plasma, 0.639±0.257 (S.D.).
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